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Most Recent Publications:
  1. “C3´and C3´N taxane derivatives; C10 taxane derivatives; C2 taxane derivatives; resistant breast cancer cells; resistant ovarian cancer cells”, Petr Daniel, Kamila Balušíková, Jaroslav Truksa, Jiří Černý, Martin Jaček, Michael Jelínek, Mutale Jane Vobruba Mulenga, Kateřina Voráčová, Lei Chen, Longfei Wei, Yi Sun, Iwao Ojima, Jan Kovár, Toxicol. Appl. Pharmacol. 489, 116993 (2024); doi: 10.1016/j.taap.2024.116993.Online ahead of print. June 12, 2024. PMID: 38870637
  2. "Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats", Isabella Dib Ferreira Gremião, Gabriela Pereira-Oliveira, Sandro Pereira, Maria Corrêa, Luana Borba-Santos, Alessandra Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel Matos, Vanessa Silva, Cristina Lazzarini, Caroline Fernandes, Kildare Miranda, Jhon Artunduaga Bonilla, Anna Nunes, Leonardo Nimrichter, Iwao Ojima, John mallamo, John McCarthy, and Maurizio Del Poeta, Spectr. 12(6), e0396723 (2024). doi: 10.1128/spectrum.03967-23. Online ahead of print Apr. 22, 2024. PMID: 38647345
  3. “Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring”, Jonathan Sun, Enric Esplugues,Alicia Bort, Magdalena P. Cardelo, Inmaculada Ruz-Maldonado,Pablo Fernández-Tussy, Clara Wong, Hehe Wang, Iwao Ojima, Martin Kaczocha, Rachel Perry, Yajaira Suárez,and Carlos Fernández-Hernando, Metab. 6(4) 741-763 (2024). doi: 10.1038/s42255-024-01019-6. Epub 2024 Apr 25. PMID: 38664583
  4. “Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma”, Tomas Sychra, Stepan Balatka, Radka Vaclavikova, Alzbeta Spalenkova, Karolina Seborova, Marie Ehrlichova, Kamila Koci, Jaroslav Truksa, Cristian Sandoval-Acuña, Tereza Tesarova, Lei Chen, Iwao Ojima, Martin Oliverius, Pavel Soucek, iScience27, 109044 (2024). https://doi.org/10.1016/j.isci.2024.109044. PMID: 38357661
  5. “SAR study of N'-(Salicylidene)heteroarenecarbohydrazides as promising antifungal agents”, Sun Y, Kim S, Shin S, Takemura K, Matos GS, Lazzarini C, Haranahalli K, Zambito J, Garg A, Del Poeta M, Ojima I. Bioorg Med Chem. 100, 117610 (2024). doi: 10.1016/j.bmc.2024.117610 (Online ahead of print on Jan. 24, 2024). PMID: 38306882
  6. “Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study”, Chris Gordon, James Trainor, Rohan J. Shah, Keith Studholme, Alex Gelman, Faniya Doswell, Faisal Sadar, Allessio Giovannetti, Josh Gershenson, Ayesha Khan, James Nicholson, ZeYu Huang, Michael Spurgat, Shao-Jun Tang, Hehe Wang, Iwao Ojima, David Carlson, David E. Komatsu, Martin Kaczocha, Osteoarthritis Cartilage, 32(3), 266-280 (2024). doi: 10.1016/j.joca.2023.11.010. Epub 2023 Nov 28.PMID: 38035977
  7. “Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxalplatin-Induced Peripheral Neuropathy”, W.G. Warren, M. Osborn, C. Tsantoulas, A. Pereira, P. Duffy, L. Ruston, H. Bradshaw, M. Kaczocha, I. Ojima, A. Yates, E. O’Sullivan, J. Pain 25(7), 104470 (2024). doi: 10.1016/j.jpain.2024.01.335 (published online on Jan. 15, 2024 ahead of print). PMID: 38232863
  8. "FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer", Manojit M. Swamynathan, Grinu Mathew, Andrei Aziz, Chris Gordon, Andrew Hillowe, Hehe Wang, Aashna Jhaveri, Jude Kendall, Hilary Cox, Michael Giarrizzo, Gissou Azabdaftari, Robert C. Rizzo, Sarah D. Diermeier, Iwao Ojima, Agnieszka B. Bialkowska, Martin Kaczocha, Lloyd C. Trotman, Cancers, 16(1), 60 (2024); https://doi.org/10.3390/cancers16010060 PMID: 38201488
  9. “Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction”, Matthew J. Jones, Taygun C. Uzuneser, Timothy Clement, Hehe Wang, Iwao Ojima, Walter J. Rushlow, Steven R. Laviolette, Psychopharmacology, 241, 119-138 (2024). (Sep 25, 2023, Online ahead of print), doi: 1007/s00213-023-06468-7. PMID: 37747506.
  10. “A Systematic Study of Key Elements Underlying Molecular Property Prediction", Jianyuan Deng, Zhibo Yang, Hehe Wang, Iwao Ojima, Dimitris Samaras, Fusheng Wang, Commun. 14, 6395 (2023). doi: 10.1038/s41467-023-41948-6 (Published online Oct 13, 2023). PMID: 37833262,PMC10575948.
  11. “Truxillic acid monoamides as fatty acid binding protein 5 inhibitors”, Chuanzhou Zhu. Livia Schutz, Kalani Jayanetti, Kathryn Takemura, Faniya Doswell, Liqun Wang, Iwao Ojima, Martin Kaczocha, Med. Chem., 94,117464 (2023). doi: 10.1016/j.bmc.2023.117464. PMID: 37708641.
  12. “Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain”, Sherrye T Glaser, Kalani Jayanetti, Saida Oubraim, Andrew Hillowe, Elena Frank, Jason Jong, Liqun Wang, Hehe Wang, Iwao Ojima, Samir Haj-Dahmane, Martin Kaczocha, Rep., 13,15234 (2023). doi: 10.1038/s41598-023-42504-4. PMID: 37709856; PMC10502087.
  13. “Fatty Acid Binding Protein 5 Regulates Docetaxel Sensitivity in Taxane-Resistant Prostate Cancer Cells”, Andrew Hillowe, Chris Gordon, Liqun Wang, Robert Rizzo, Lloyd Trotman, Iwao Ojima, Agnieszka Bialkowska, Martin Kaczocha, PLOS ONE, 18, e0292483 (2023). https://doi.org/10.1371/journal.pone.0292483. PMID: 37796964; PMC10553314.
  14. “Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex”, C. Uzuneser,H. J. Szkudlarek, M. J. Jones, M. G. Nashed, T. Clement, H. Wang, I. Ojima, W. J. Rushlow, S. R. Laviolette, Celeb. Cortex, 33 (6), 2470-2484 (2023). https://doi.org/10.1093/cercor/bhac220. PMC10016066.
  15. “Targeting sterylglucosidase A to treat Aspergillus 1 fumigatus infections”, Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V. Airola, Maurizio Del Poeta, mBio14, e0033923 (2023). https://doi.org/10.1128/mbio.00339-23.PMID: 36877042;
  16. “ABCB1 amplicon contains cyclic AMP response element-driven TRIP6 gene in taxane-resistant MCF-7 breast cancer sublines”, Petr Daniel, Kamila Balušíková, Radka Václavíková, Karolína, Šeborová, Šárka Ransdorfová, Marie Valeriánová, Longfei Wei, Michael Jelínek, Tereza Tlapáková, Thomas Fleischer, Vessela N. Kristensen, Pavel

    Souček *, Iwao Ojima, Jan Kovář, Genes14, 296 (2023). https://www.mdpi.com/2073-4425/14/2/296. PMID: 36833223; PMC9957548
  17. “Identification of a Novel Fatty Acid Binding Protein-5-CB2 Receptor Dependent Mechansim Regulating Anxiety Behaviors in the Prefrontal Cortel”, Taygun C. Uzuneser, Hanna J. Szkudlarek, Matthew J. Jones, Mina G. Nashed, Timothy Clement, Hehe Wang, Iwao Ojima, Walter J. Rushlow and Steven R. Laviolette, Cerebral Cortex, 33(6), 2470-2484 (2023). https://doi.org/10.1093/cercor/bhac220. PMID: 35650684; PMC10016066
  18. “Taking a Respite from Representation Learning for Molecular Property Prediction”, Jianyuan Deng, Zhibo Yang, Hehe Wang, Iwao Ojima, Dimitris Samaras, and Fusheng Wang, arXiv:2209.13492 (2022).
  19. “Third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model”,  Karolina Seborova, Kamila Koucka, Alzbeta Spalenkova, Petr Holy, Marie Ehrlichova, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek anRadka Vaclavikova, Pharmacol. 13, 971905 (2022). https://doi.org/10.3389/fphar.2022.971905. PMID: 36438837; PMC9681785.
  20. “SAR Study on Novel Truxillic Acid Monoesters Targeting Fatty Acid Binding Proteins as Next-Generation antinociceptive Agents”, Hehe Wang, Adam Taouil, Monaf Awwa, Timothy Clement, Chuanzhou Zhu, Jinwoo Kim, Dominick Rendina, Kalani Jayanetti, Atri Maharaj, Liqun Wang, Diane Bogdan, Antonella Pepe, Martin Kaczocha, and Iwao Ojima, Chem. 129, 106184 (2022). https://doi.org/10.1016/j.bioorg.2022.106184. PMID: 36244323.
  21. “Targeting the Bet-Hedging Strategy with an Inhibitor of Bacterial Efflux Capacity Enhances Antibiotic Efficiency and Ameliorates Bacterial Persistence In Vitro”, Demosthenes Morales, Sofiya Micheva-Viteva, Samantha Adikari 1, James Werner, Murray Wolinsky, Elizabeth Hong-Geller, Jinwoo Kim and Iwao Ojima, Microorganisms, 10, 1966 (2022). https://doi.org/10.3390/microorganisms10101966. PMID: 36296242; PMCID: PMC9609472
  22. “Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids”, Changwei Wang, Lei Chen, Yi Sun, Wanrong Guo, Adam K.Taouil, Iwao Ojima, Chem., 119, 105578 (2022). https://doi.org/10.1016/j.bioorg.2021.105578. PMID: 34979464
  23. “The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes”, Karolina Seborova, Alzbeta Kloudova-Spalenkova, Kamila Koucka, Petr Holy, Marie Ehrlichova, Changwei Wang, Iwao Ojima, Iveta Voleska, Petr Daniel, Kamila Balusikova, Michael Jelinek, Jan Kovar, Lukas Rob, Martin Hruda, Marcela Mrhalova, Pavel Soucek, Radka Vaclavikova, J. Mol. Sci. 23, 73 (2022). https://doi.org/10.3390/ijms23010073. PMID: 35008510; PMC8744980
  24. “Potent Antitumor Activity of Novel Taxoids in Anaplastic Thyroid Cancer”, Wang, Meichen; Wang, Changwei; Feng, Chao; Guo, Wanrong; Chen, Huan; Liu, Bing; Li, Enxiao; Liu, Wei; Taouil, Adam; Ojima, Iwao;Hou, Peng, 75, 465-477 (2022). E-pub ahead of print (9/30/2021): https://doi.org/10.1007/s12020-021-02880-1. PMID: 34591230
  25. “Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents”, Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola, Commun. 12(1), 5885 (2021). https://doi:10.1038/s41467-021-26163-5. PMID: 34620873; PMC8497620
  26. “Use of Acylhydrazone derivatives as a New therapy for Sporotrichosis”, Jhon Jhamilton Artunduaga Bonilla, Leandro Honorato, Krupanandan Haranahalli, Isabella Dib Ferreira Gremião, Sandro Antonio Pereira, Allan J. Guimaraes, Andrea Regina De Souza Baptista, Patrícia De Mello Tavares, Marcio Lourenço Rodrigues, Kildare Miranda, Iwao Ojima, Maurizio Del Poeta and Leonardo Nimrichter, Agents Chemother. 65(5), e02593-20 (2021); https://doi.org/10.1128/AAC.02593-20. PMID: 33593845; PMC8092869
  27. “Structure-Activity Relationship Studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents”, Krupanandan Haranahalli, Simon Tong, Saerom Kim, Monaf Awwa, Susan E. Knudson, Richard A. Slayden, Eric Singleton, Riccardo Russo, Nancy Connell and Iwao Ojima, RSC Med. Chem. 12, 78-94 (2021). https://doi.org/10.1039/D0MD00256A. PMID: 34046600; PMC8132993
  28. “Endocannabinoid mechanism and transport as target to regulate intramolecular pressure”, Sally Miller, Laura Daily, Vijai Dharla, Juerg Gertsch, Michael S. Malamas, Iwao Ojima, Martin Kaczocha, Daisuke Ogasawara, Alex Straiker, Eye Res. 201, 108266 (2020). doi: 10.1016/j.exer.2020.108266. Online ahead of print. PMID: 32979397; PMC8054225
  29. “A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance in breast cancer cells”, Dade Rong, Changwei Wang, Xiaomei Zhang, Yanli Wei, Mingming Zhang, Daiyuan Liu, Haider Farhan, Saleh Abdul Momen Ali, Yanbin Liu, Adam Taouil, Wanrong Guo, Yican Wang, Iwao Ojima*, Shulan Yang*, Haihe Wang*, Cancer Lett.491, 36-49 (2020). DOI: 1016/j.canlet.2020.06.025. PMID: 32730778
  30. “Preclinical evaluation of acylhydrazone SB-AF-1002 as a novel broad-spectrum antifungal agent”, Cristina Lazzarini, Krupanandan Haranahalli, J. Brian McCarthy, John Mallamo, Iwao Ojima, Maurizio Del Poeta, Agents Chemother. 64(9):e00946-20 (2020). doi: 10.1128/AAC.00946-20. PMID: 32601165; PMC7449198
 
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